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In vivo research show anatomically selective neurochemical outcomes of modafinil on monoaminergic methods (de Saint Hilaire et al 2001; Ferraro et al 2002), and, notably, though modafinil will increase TMN fos expression (Scammell et al 2000) and HAergic tone it can be not able to exert this outcome when administered straight into the TMN (Ishizuka